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If indicated on the product package, shake the medicine before use. Systemic prednisolone is metabolized by the liver to sulfate and glucuronide conjugates. These inactive metabolites, as well as a small portion of unchanged drug, are excreted in the urine. Prednisolone is eliminated from the plasma with a half-life of 2—4 hours; however, the biological half-life is 18—36 hours.
Bacterial keratitis has been reported in patients who have received ophthalmic preparations that were dispensed in multidose containers. This reaction most likely is due to contamination of the solution, so patients should be instructed not to allow the tip of the applicator to touch the eye or any other surfaces. Pharmacological doses of systemic corticosteroids administered for prolonged periods may result in hypothalamic-pituitary-adrenal suppression and/or manifestations of Cushing's syndrome in some patients. Acute adrenal insufficiency and even death may occur following abrupt discontinuation of systemic therapy. In addition, a withdrawal syndrome unrelated to adrenocortical insufficiency may occur following sudden discontinuation of corticosteroid therapy. These effects are thought to be due to the sudden change in glucocorticoid concentration rather than to low corticosteroid levels.
If you’re pregnant or planning to become pregnant while taking prednisolone, talk with your doctor. They’ll discuss the risks and benefits of prednisolone treatment with you. Half-life is the time it takes your body to get rid of half of a drug’s dose. For prednisolone, this means it takes about 2.6 hours for your body to get rid of half a dose. Doctors won’t directly prescribe prednisolone to treat a cough.
Naturally occurring glucocorticoids (hydro-cortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs such as prednisolone are primarily used for their potent anti-inflammatory effects in disorders of many organ systems. The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction should be gradual.
Such effects occur if this medicine is used during the first three months of the pregnancy. Long term use of Prelone is linked to negative effects on growth and development in children. Monitor for such effects especially if using this medicine for a long time. Consult with your doctor on the use of Prelone Syrup during pregnancy.
Prednisolone may also be used off-label for other conditions. Off-label drug use is when an FDA-approved drug is prescribed for a purpose other than what it’s approved for. The drug manufacturer hasn’t provided a “normal” dose or maximum dose of prednisolone. Some conditions may require a low dose of prednisolone, such as 5 mg daily. Other conditions may require a higher dosage, such as 40 mg daily.
Prelone Syrup interacts with anticholinesterase agents, which are used to treat neurodegenerative conditions such as dementia, Parkinson's disease, and Alzheimer's disease. The combined use of anticholinesterase agents and corticosteroids may cause severe weakness in the skeletal muscles. Anticholinesterase agents should be discontinued at least 24 hours before receiving corticosteroid treatment. The body's ability to fight new infections is reduced and existing infections may get masked. These infections include tubercolosis, chickenpox, measles, threadworm infestations, amebiasis and cerebral malaria.
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